TY - JOUR
KW - Adult
KW - Antigens, Bacterial
KW - B-Lymphocytes
KW - Dose-Response Relationship, Immunologic
KW - Epitopes
KW - Female
KW - Humans
KW - Hydrocortisone
KW - Immunoglobulin M
KW - Indomethacin
KW - leprosy
KW - Lymphocyte Activation
KW - Male
KW - Middle Aged
KW - Mycobacterium
KW - T-Lymphocytes
AU - Fleming B
AU - Rook G A
AB - <p>Soluble extracts of ultrasonically disrupted mycobacteria (including Mycobacterium leprae) cause strong T-cell-dependent, Cyclosporin A-sensitive, polyclonal B-cell activation, in human peripheral blood mononuclear cell preparations. It is not enhanced by cortisol. Cells from cases of lepromatous leprosy show no polyclonal B-cell activation in the presence of extracts of M. leprae, although they respond normally to other mycobacterial species. The polyclonal B-cell activation response to the M. leprae extract, of a small group of normal leprosy contacts, was reduced relative to that of non-contacts.</p>
BT - Immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6183191?dopt=Abstract
DA - 1982 Dec
IS - 4
J2 - Immunology
LA - eng
N2 - <p>Soluble extracts of ultrasonically disrupted mycobacteria (including Mycobacterium leprae) cause strong T-cell-dependent, Cyclosporin A-sensitive, polyclonal B-cell activation, in human peripheral blood mononuclear cell preparations. It is not enhanced by cortisol. Cells from cases of lepromatous leprosy show no polyclonal B-cell activation in the presence of extracts of M. leprae, although they respond normally to other mycobacterial species. The polyclonal B-cell activation response to the M. leprae extract, of a small group of normal leprosy contacts, was reduced relative to that of non-contacts.</p>
PY - 1982
SP - 589
EP - 95
T2 - Immunology
TI - T-cell-dependent polyclonal activation by soluble mycobacterial extracts of B cells in peripheral blood mononuclear cell populations from leprosy patients and normal donors.
VL - 47
SN - 0019-2805
ER -