Biopsies from 2 patients clinically diagnosed and confirmed by histopathological studies as histoid leprosy were examined using and electronmicroscope. The cells that form the nodule are found to contain far more solid bacilli and much less electron transparent substance than those in lepromatous lesions. They have the characteristics of both macrophages and fibroblasts. It is reasonable to conclude that they are histiocytes produced by local multiplication in response to stimulation by rapidly proliferating M. leprae rather than from accumulation of blood monocytes at the site of inflammation as lepromatous lesions.
BT - Leprosy in India C1 - http://www.ncbi.nlm.nih.gov/pubmed/604655?dopt=Abstract CN - Infolep Library - available DA - 1977 Oct IS - 4 J2 - Lepr India LA - eng N2 -Biopsies from 2 patients clinically diagnosed and confirmed by histopathological studies as histoid leprosy were examined using and electronmicroscope. The cells that form the nodule are found to contain far more solid bacilli and much less electron transparent substance than those in lepromatous lesions. They have the characteristics of both macrophages and fibroblasts. It is reasonable to conclude that they are histiocytes produced by local multiplication in response to stimulation by rapidly proliferating M. leprae rather than from accumulation of blood monocytes at the site of inflammation as lepromatous lesions.
PY - 1977 SP - 467 EP - 71 T2 - Leprosy in India TI - Electromicroscopic study of histoid leprosy with special reference to its histogenesis. VL - 49 SN - 0024-1024 ER -