TY - JOUR
KW - Antibodies
KW - Antibody Specificity
KW - Apoptosis
KW - CD28 Antigens
KW - Cells, Cultured
KW - Cytokines
KW - Humans
KW - Interleukin-1
KW - Interleukin-6
KW - Ionomycin
KW - leprosy
KW - Leukocytes, Mononuclear
KW - Tumor Necrosis Factor-alpha
KW - Zinc
AU - Gupta A
AU - Sharma V K
AU - Vohra H
AU - Ganguly N K
AB - <p>Peripheral blood mononuclear cells from leprosy patients underwent spontaneous apoptosis upon culture for 24 h. The apoptosis was inhibited by anti-TNFalpha antibodies and to a certain extent by anti-IL-1alpha and IL-6, thus showing that T(H)2-type cytokines (mainly TNFalpha) are responsible for inducing apoptosis. This cytokine-mediated apoptosis could be inhibited by ionomycin and zinc, thereby suggesting that these metal ions can be used to decrease the levels of these inflammatory cytokines in various diseases.</p>
BT - FEMS immunology and medical microbiology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10340712?dopt=Abstract
DA - 1999 May
DO - 10.1111/j.1574-695X.1999.tb01264.x
IS - 1
J2 - FEMS Immunol. Med. Microbiol.
LA - eng
N2 - <p>Peripheral blood mononuclear cells from leprosy patients underwent spontaneous apoptosis upon culture for 24 h. The apoptosis was inhibited by anti-TNFalpha antibodies and to a certain extent by anti-IL-1alpha and IL-6, thus showing that T(H)2-type cytokines (mainly TNFalpha) are responsible for inducing apoptosis. This cytokine-mediated apoptosis could be inhibited by ionomycin and zinc, thereby suggesting that these metal ions can be used to decrease the levels of these inflammatory cytokines in various diseases.</p>
PY - 1999
SP - 49
EP - 55
T2 - FEMS immunology and medical microbiology
TI - Spontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines.
VL - 24
SN - 0928-8244
ER -