TY - JOUR
KW - Amyloidosis
KW - Blood Proteins
KW - Erythema Nodosum
KW - Humans
KW - leprosy
KW - Leukocyte Count
KW - Leukocytosis
KW - Neutrophils
KW - Recurrence
AU - McAdam K P
AU - Anders R F
AU - Smith S R
AU - Russell D A
AU - Price M A
AB - <p>Rectal biopsy in 190 inpatients at a leprosy hospital in the Highlands of Papua New Guinea disclosed 16 patients with secondary amyloidosis. This represented 20% of the patients who had had polar lepromatous leprosy (L.L.) for more than 2 years. Patients with amyloidosis characteristically had either a history of recurrent attacks of erythema nodosum leprosum (E.NH) reactions or chronic trophic ulcers. Levels of the serum component (protein SAA) antigenically related to the amyloid fibril protein AA were monitored, at varying intervals for three months, in lepromatous patients with E.N.L. reaction. The SAA levels rose during E.N.L. reactions in parallel with the neutrophil count. SAA occurred with greatest frequency among patients with LH, while most non-lepromatous patients with detectable SAA had chronic trophic ulcers. The correlation between raised neutrophil count and elevated SAA concentration, observed in this and other studies, suggests that neutrophils are associated with the production of SAA.</p>
BT - Lancet (London, England)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/51405?dopt=Abstract
DA - 1975 Sep 27
DO - 10.1016/s0140-6736(75)90168-3
IS - 7935
J2 - Lancet
LA - eng
N2 - <p>Rectal biopsy in 190 inpatients at a leprosy hospital in the Highlands of Papua New Guinea disclosed 16 patients with secondary amyloidosis. This represented 20% of the patients who had had polar lepromatous leprosy (L.L.) for more than 2 years. Patients with amyloidosis characteristically had either a history of recurrent attacks of erythema nodosum leprosum (E.NH) reactions or chronic trophic ulcers. Levels of the serum component (protein SAA) antigenically related to the amyloid fibril protein AA were monitored, at varying intervals for three months, in lepromatous patients with E.N.L. reaction. The SAA levels rose during E.N.L. reactions in parallel with the neutrophil count. SAA occurred with greatest frequency among patients with LH, while most non-lepromatous patients with detectable SAA had chronic trophic ulcers. The correlation between raised neutrophil count and elevated SAA concentration, observed in this and other studies, suggests that neutrophils are associated with the production of SAA.</p>
PY - 1975
SP - 572
EP - 3
T2 - Lancet (London, England)
TI - Association of amyloidosis with erythema nodosum leprosum reactions and recurrent neutrophil leucocytosis in leprosy.
VL - 2
SN - 0140-6736
ER -