TY - JOUR KW - Adolescent KW - Adult KW - Age Factors KW - Antibodies, Bacterial KW - Antigens, Bacterial KW - Child KW - Child, Preschool KW - Enzyme-Linked Immunosorbent Assay KW - Female KW - Glycolipids KW - Humans KW - Immunoglobulin M KW - India KW - Infant KW - leprosy KW - Longitudinal studies KW - Male KW - Middle Aged KW - Mycobacterium leprae KW - Prevalence KW - Sex Factors AU - Krishnamurthy P AU - Rao P S AU - Reddy B N AU - Subramanian M AU - Dhandayudapani S AU - Bhatia V AU - Neelan P N AU - Dutta A AB -

As part of a continuing longitudinal immuno-epidemiological study, blood samples were collected by finger prick from 4243 individuals living in a highly endemic area for leprosy in South India. The samples were tested for IgM antibodies against phenolic glycolipid-I using an ELISA. Seropositivity defined as optical density greater than or equal to 0.2000 was marginally higher in the age group 10-30 years and in females. There was no evidence for a higher level in contacts than in non-contacts. The future prospect for the large scale use of this ELISA in high-endemic populations in special epidemiological investigations or routine control programs as a serological tool to detect leprosy infection appears questionable.

BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 -

http://www.ncbi.nlm.nih.gov/pubmed/1890366?dopt=Abstract

DA - 1991 Sep IS - 3 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -

As part of a continuing longitudinal immuno-epidemiological study, blood samples were collected by finger prick from 4243 individuals living in a highly endemic area for leprosy in South India. The samples were tested for IgM antibodies against phenolic glycolipid-I using an ELISA. Seropositivity defined as optical density greater than or equal to 0.2000 was marginally higher in the age group 10-30 years and in females. There was no evidence for a higher level in contacts than in non-contacts. The future prospect for the large scale use of this ELISA in high-endemic populations in special epidemiological investigations or routine control programs as a serological tool to detect leprosy infection appears questionable.

PY - 1991 SP - 426 EP - 31 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Seroepidemiological study of leprosy in a highly endemic population of south India based on an ELISA using synthetic PGL-I. UR - http://ila.ilsl.br/pdfs/v59n3a06.pdf VL - 59 SN - 0148-916X ER -