TY - JOUR
KW - Female
KW - Gene Frequency
KW - HLA Antigens
KW - Histocompatibility Testing
KW - Humans
KW - India
KW - leprosy
KW - Male
KW - Mycobacterium Infections
KW - Mycobacterium Infections, Nontuberculous
KW - Phenotype
AU - Eden W
AU - Mehra N K
AU - Vaidya M C
AU - D'Amaro J
AU - Schreuder G M
AU - Rood J J
AB - <p>A population study to test whether associations between HLA and sporadic--i.e. non-familial--tuberculoid leprosy exist was undertaken in a hyperendemic area in India. Since previous family studies in the same area had shown both non-random haplotype segregation in the family members affected with tuberculoid leprosy and the preferential segregation of HLA-DR2 into tuberculoid leprosy patients, an increased frequency of DR2 among the "sporadic" patients was expected. However, no heterogeneity for HLA was detected between patients and controls. These findings could indicate that tuberculoid leprosy is a heterogeneous disease with regard to genetic background.</p>
BT - Tissue antigens
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7336423?dopt=Abstract
DA - 1981 Sep
DO - 10.1111/j.1399-0039.1981.tb01381.x
IS - 3
J2 - Tissue Antigens
LA - eng
N2 - <p>A population study to test whether associations between HLA and sporadic--i.e. non-familial--tuberculoid leprosy exist was undertaken in a hyperendemic area in India. Since previous family studies in the same area had shown both non-random haplotype segregation in the family members affected with tuberculoid leprosy and the preferential segregation of HLA-DR2 into tuberculoid leprosy patients, an increased frequency of DR2 among the "sporadic" patients was expected. However, no heterogeneity for HLA was detected between patients and controls. These findings could indicate that tuberculoid leprosy is a heterogeneous disease with regard to genetic background.</p>
PY - 1981
SP - 189
EP - 94
T2 - Tissue antigens
TI - HLA and sporadic tuberculoid leprosy: a population study in Maharashtra, India.
VL - 18
SN - 0001-2815
ER -