TY - JOUR
KW - Adult
KW - Aged
KW - Animals
KW - Blood Cell Count
KW - Clofazimine
KW - Dapsone
KW - Erythema Nodosum
KW - Erythrocytes
KW - Humans
KW - Immune Adherence Reaction
KW - leprosy
KW - Middle Aged
KW - Phenazines
KW - Sheep
KW - T-Lymphocytes
AU - Lim S D
AU - Kiszkiss D F
AU - Jacobson R R
AU - Choi Y S
AU - Good R A
AB - <p>Study of the numbers of thymus-derived lymphocytes by the rosette assay (T-RFC) in patients with leprosy reveals that lower than normal numbers of T-RFC are regularly seen in those patients with the active lepromatous form of this disease. Essentially normal numbers of T-RFC were found in inactive lepromatous, borderline, and indeterminate types of leprosy. The lowest percentages and lowest absolute numbers of T-RFC were encountered in patients with lepromatous leprosy resistant to chemotherapy. Patients with lepromatous leprosy complicated by erythema nodosum leprosum show numbers of T-RFC that are more nearly normal than the numbers of T-RFC in patients with uncomplicated lepromatous leprosy. These findings are discussed with respect to the pathogenesis of lepromatous leprosy and the T-RFC deficiency demonstrated in this disease. The possibility that transient defects in T-RFC numbers or function may predispose to lepromatous leprosy is proposed.</p>
BT - Infection and immunity
C1 - http://www.ncbi.nlm.nih.gov/pubmed/4544619?dopt=Abstract
DA - 1974 Feb
IS - 2
J2 - Infect. Immun.
LA - eng
N2 - <p>Study of the numbers of thymus-derived lymphocytes by the rosette assay (T-RFC) in patients with leprosy reveals that lower than normal numbers of T-RFC are regularly seen in those patients with the active lepromatous form of this disease. Essentially normal numbers of T-RFC were found in inactive lepromatous, borderline, and indeterminate types of leprosy. The lowest percentages and lowest absolute numbers of T-RFC were encountered in patients with lepromatous leprosy resistant to chemotherapy. Patients with lepromatous leprosy complicated by erythema nodosum leprosum show numbers of T-RFC that are more nearly normal than the numbers of T-RFC in patients with uncomplicated lepromatous leprosy. These findings are discussed with respect to the pathogenesis of lepromatous leprosy and the T-RFC deficiency demonstrated in this disease. The possibility that transient defects in T-RFC numbers or function may predispose to lepromatous leprosy is proposed.</p>
PY - 1974
SP - 394
EP - 9
T2 - Infection and immunity
TI - Thymus-dependent lymphocytes of peripheral blood in leprosy patients.
VL - 9
SN - 0019-9567
ER -