TY - JOUR
KW - Adenocarcinoma
KW - Animals
KW - Antibodies, Viral
KW - Antilymphocyte Serum
KW - Humans
KW - Immunity, Maternally-Acquired
KW - Immunization
KW - Immunosuppression
KW - leprosy
KW - Lung Neoplasms
KW - Mammary Neoplasms, Experimental
KW - Mice
KW - Mice, Inbred CBA
KW - Neoplasms, Experimental
KW - Osteosarcoma
KW - Polyomavirus
KW - Sarcoma, Experimental
KW - Spleen
KW - Thymectomy
AU - Gaugas J M
AU - Allison A C
AU - Chesterman F C
AU - Rees R J
AU - Hirsch M S
AB - <p>Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions.</p>
BT - British journal of cancer
C1 - http://www.ncbi.nlm.nih.gov/pubmed/4346752?dopt=Abstract
DA - 1973 Jan
DO - 10.1038/bjc.1973.2
IS - 1
J2 - Br. J. Cancer
LA - eng
N2 - <p>Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions.</p>
PY - 1973
SP - 10
EP - 7
T2 - British journal of cancer
TI - Immunological control of polyoma virus oncogenesis in mice.
VL - 27
SN - 0007-0920
ER -