TY - JOUR
KW - Antibodies, Bacterial
KW - Antibody Formation
KW - Antigens, Bacterial
KW - Autoantibodies
KW - B-Lymphocytes
KW - Graft Rejection
KW - Humans
KW - Hypersensitivity, Delayed
KW - Immunity, Cellular
KW - Immunoglobulins
KW - Lepromin
KW - leprosy
KW - Lymphocyte Activation
KW - Lymphocyte Culture Test, Mixed
KW - Macrophages
KW - Mycobacterium leprae
KW - Peripheral Nervous System Diseases
KW - Phagocytosis
KW - Skin Transplantation
KW - T-Lymphocytes
KW - Transplantation, Autologous
AB - <p>This Memorandum reviews the present status of knowledge of the immunology of leprosy, with particular attention to developments since the publication of a similar review in 1970. The different types of lepromin reaction and their significance in healthy contacts and in patients with tuberculoid and lepromatous leprosy are discussed. The immunological responsiveness of patients with leprosy is also considered, with special attention to in vitro methods for evaluating this response. Part 2 of the Memorandum will cover possible mechanisms of altered immune response in leprosy (including a tentative scheme to explain the possible genesis of the lepromatous lesion); genetic, nutritional, and hormonal factors; the possibility of vaccination; attempts at immunotherapy; and areas in which further research is needed. A detailed protocol for evaluating the effect of transfer factor in leprosy will be included as an annex.</p>
BT - Bulletin of the World Health Organization
C1 - http://www.ncbi.nlm.nih.gov/pubmed/4355402?dopt=Abstract
DA - 1973
IS - 3
J2 - Bull. World Health Organ.
LA - eng
N2 - <p>This Memorandum reviews the present status of knowledge of the immunology of leprosy, with particular attention to developments since the publication of a similar review in 1970. The different types of lepromin reaction and their significance in healthy contacts and in patients with tuberculoid and lepromatous leprosy are discussed. The immunological responsiveness of patients with leprosy is also considered, with special attention to in vitro methods for evaluating this response. Part 2 of the Memorandum will cover possible mechanisms of altered immune response in leprosy (including a tentative scheme to explain the possible genesis of the lepromatous lesion); genetic, nutritional, and hormonal factors; the possibility of vaccination; attempts at immunotherapy; and areas in which further research is needed. A detailed protocol for evaluating the effect of transfer factor in leprosy will be included as an annex.</p>
PY - 1973
SP - 345
EP - 54
T2 - Bulletin of the World Health Organization
TI - Immunological problems in leprosy research. 1.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481057/pdf/bullwho00176-0081.pdf
VL - 48
SN - 0042-9686
ER -