TY - JOUR
KW - Antibodies, Viral
KW - Antibody Formation
KW - Antigens, Viral
KW - Complement Fixation Tests
KW - Cytomegalovirus
KW - Fluorescent Antibody Technique
KW - Herpesvirus 4, Human
KW - Humans
KW - Immunity, Cellular
KW - Immunodiffusion
KW - Immunoglobulin G
KW - leprosy
AU - Papageorgiou P S
AU - Sorokin C F
AU - Kouzoutzakoglou K
AU - Bonforte R J
AU - Workman P L
AU - Glade P R
AB - <p>A study was undertaken in patients with leprosy to assess the contribution of cell-mediated immunity to the host response to Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. Sixteen of 72 patients (22%) with lepromatous leprosy, with impaired cellular immunity, had anti-EBV titers of 1,640 or higher. Only 4 of 49 patients (8%) with tuberculoid leprosy, with intact cell-mediated immunity, attained the level of 1:640. The anti-EBV antibody titers were significantly higher in patients with lepromatous leprosy (P approximately 0.025). No significant differences were found in the level of anti-CMV antibody titers in patients with the two types of leprosy. The presence of high anti-EBV antibody titers in lepromatous leprosy suggests that cell-mediated immunity is a significant factor in host response to EBV infection. Host immune responses should be taken into consideration when assignment of an etiological role to EBV is based upon seroepidemiological data.</p>
BT - Infection and immunity
C1 - http://www.ncbi.nlm.nih.gov/pubmed/4357604?dopt=Abstract
DA - 1973 Apr
IS - 4
J2 - Infect. Immun.
LA - eng
N2 - <p>A study was undertaken in patients with leprosy to assess the contribution of cell-mediated immunity to the host response to Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infection. Sixteen of 72 patients (22%) with lepromatous leprosy, with impaired cellular immunity, had anti-EBV titers of 1,640 or higher. Only 4 of 49 patients (8%) with tuberculoid leprosy, with intact cell-mediated immunity, attained the level of 1:640. The anti-EBV antibody titers were significantly higher in patients with lepromatous leprosy (P approximately 0.025). No significant differences were found in the level of anti-CMV antibody titers in patients with the two types of leprosy. The presence of high anti-EBV antibody titers in lepromatous leprosy suggests that cell-mediated immunity is a significant factor in host response to EBV infection. Host immune responses should be taken into consideration when assignment of an etiological role to EBV is based upon seroepidemiological data.</p>
PY - 1973
SP - 620
EP - 4
T2 - Infection and immunity
TI - Host responses to Epstein-Barr virus and cytomegalovirus infection in leprosy.
VL - 7
SN - 0019-9567
ER -