In order to study the role of genetic factors in susceptibility to leprosy infection, the prevalence of leprosy in 118 pairs of Burmese villages different distances apart was investigated. The distribution pattern of the correlation coefficients for leprosy rates was compared with that known to occur for genetic markers under similar conditions. The correlation coefficients decreased rapidly as the distance between the pairs of villages increased and then showed periodicity with distance, becoming negative at almost regular intervals of 4 km: negative values were preponderant for villages more than 25 km apart. Thus with this set of correlations it was not possible to fit a monotonically decreasing function of the type that would fit similar data for a genetic marker
BT - Bulletin of the World Health Organization C1 - http://www.ncbi.nlm.nih.gov/pubmed/4268970?dopt=Abstract CN - BECHELLI1973 DA - 1973 IS - 2 J2 - Bull. World Health Organ. LA - eng N2 -In order to study the role of genetic factors in susceptibility to leprosy infection, the prevalence of leprosy in 118 pairs of Burmese villages different distances apart was investigated. The distribution pattern of the correlation coefficients for leprosy rates was compared with that known to occur for genetic markers under similar conditions. The correlation coefficients decreased rapidly as the distance between the pairs of villages increased and then showed periodicity with distance, becoming negative at almost regular intervals of 4 km: negative values were preponderant for villages more than 25 km apart. Thus with this set of correlations it was not possible to fit a monotonically decreasing function of the type that would fit similar data for a genetic marker
PY - 1973 SP - 257 EP - 60 T2 - Bulletin of the World Health Organization TI - Correlation between leprosy rates in villages different distances apart. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481009/pdf/bullwho00175-0118.pdf VL - 48 SN - 0042-9686 ER -