TY - JOUR
KW - Antibodies, Antineutrophil Cytoplasmic
KW - Autoimmune Diseases
KW - HLA-A1 Antigen
KW - HLA-B Antigens
KW - HLA-B40 Antigen
KW - Humans
KW - Immunogenetics
KW - India
KW - leprosy
KW - Malaria
KW - Vasculitis
AU - Shankarkumar U
AU - Ghosh K
AU - Pradhan V D
AU - Badakere S S
AU - Mohanty D
AB - <p>Considerable genetic evidence exit for ANCA-associated vasculitis and pathogenesis. HLA A and B alleles identified serologically from 84 ANCA-positive patients were compared with 101 controls. Further subtyping were done in the 27 "pauci-immune" vasculitis patients using the polymerase chain reaction based PCR-SSOP technique and compared with controls (67). The results revealed that HLA A1 (OR=4.00; p value 2.72E-05), B17 (OR=3.38; p value 0.0008) and HLA B40 (OR=2.74; p value 0.001) were significantly increased among ANCA-positive patients when compared with the controls. Further, the molecular subtypes A*0101 (OR=5.04; p value 0.0005), B*5801 (OR=4.47; p value 0.0002) and haplotype A*0101-B*5801 (OR=4.47; p value 0.0001) were significantly increased among the autoimmune patients. The study revealed that HLA A1, B17 and B40 alleles are associated in production of antineutrophil autoantibodies and A*0101-B*5801 haplotype is significantly associated with autoimmune diseases and they may be invariably involved in disease pathogenesis in India.</p>
BT - Journal of autoimmunity
C1 - http://www.ncbi.nlm.nih.gov/pubmed/15848045?dopt=Abstract
DA - 2005 May
DO - 10.1016/j.jaut.2005.01.009
IS - 3
J2 - J. Autoimmun.
LA - eng
N2 - <p>Considerable genetic evidence exit for ANCA-associated vasculitis and pathogenesis. HLA A and B alleles identified serologically from 84 ANCA-positive patients were compared with 101 controls. Further subtyping were done in the 27 "pauci-immune" vasculitis patients using the polymerase chain reaction based PCR-SSOP technique and compared with controls (67). The results revealed that HLA A1 (OR=4.00; p value 2.72E-05), B17 (OR=3.38; p value 0.0008) and HLA B40 (OR=2.74; p value 0.001) were significantly increased among ANCA-positive patients when compared with the controls. Further, the molecular subtypes A*0101 (OR=5.04; p value 0.0005), B*5801 (OR=4.47; p value 0.0002) and haplotype A*0101-B*5801 (OR=4.47; p value 0.0001) were significantly increased among the autoimmune patients. The study revealed that HLA A1, B17 and B40 alleles are associated in production of antineutrophil autoantibodies and A*0101-B*5801 haplotype is significantly associated with autoimmune diseases and they may be invariably involved in disease pathogenesis in India.</p>
PY - 2005
SP - 227
EP - 33
T2 - Journal of autoimmunity
TI - Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India.
VL - 24
SN - 0896-8411
ER -