TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Animals
KW - Biopsy
KW - Chick Embryo
KW - Child
KW - Female
KW - Glycosaminoglycans
KW - Histological Techniques
KW - Humans
KW - Hyaluronic Acid
KW - leprosy
KW - Male
KW - Microscopy
KW - Mycobacterium leprae
KW - Skin
KW - Staining and Labeling
KW - Tuberculoma
AU - Skinsnes O K
AU - Matsuo E
AB - <p>A histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. In contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. The macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tuberculoid in BT cases and the lepromatous expression in BL cases. It is suggested that hyaluronic acid, in a manner similar to M. leprae and lipid, has a quantitatively varied distribution reflecting the immunopathologic spectrum of leprosy. This finding suggests that acid mucopolysaccharide may be significantly involved in that host/parasite interaction in leprosy.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/4142476?dopt=Abstract
DA - 1974 Oct-Dec
IS - 4
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>A histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. In contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. The macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tuberculoid in BT cases and the lepromatous expression in BL cases. It is suggested that hyaluronic acid, in a manner similar to M. leprae and lipid, has a quantitatively varied distribution reflecting the immunopathologic spectrum of leprosy. This finding suggests that acid mucopolysaccharide may be significantly involved in that host/parasite interaction in leprosy.</p>
PY - 1974
SP - 392
EP - 8
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Acid mucopolysaccharide metabolism in leprosy. 1. Storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy.
UR - http://ila.ilsl.br/pdfs/v42n4a02.pdf
VL - 42
SN - 0148-916X
ER -