TY - JOUR KW - Adolescent KW - Adult KW - Clofazimine KW - Female KW - Gastrointestinal Diseases KW - Humans KW - Intestinal Absorption KW - Intestine, Small KW - leprosy KW - Male KW - Middle Aged AU - Bhasin D K AU - Kumar B AU - Broor S L AU - Kaur S AU - Malik A M AU - Mehra S K AB -

Twenty one patients of leprosy were studied for gastrointestinal symptoms and submitted to detailed intestinal absorption tests and jejunal biopsy before and after the institution of Clofazimine therapy. Fifteen patients were administered 100 mg orally daily for 3 months, while six patients with ENL received 300 mg of the drug for 6 weeks initially and then 100 mg daily. Mild diarrhoea and abdominal symptoms occurred in four patients, fecal fat excretion increased in one patient but Schilling's and d-Xylose tests did not alter. No significant changes were produced by Clofazimine therapy in jejunal mucosa. Clofazimine crystals were seen in the lamina properia of one patient, the overlying mucosa was normal. No correlation was found between the abnormality in mucosal pattern, crystal deposition, absorption parameters or symptomatology and doses of drug taken.

BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/4078364?dopt=Abstract CN - Infolep Library - available DA - 1985 Apr-Jun IS - 2 J2 - Indian J Lepr LA - eng N2 -

Twenty one patients of leprosy were studied for gastrointestinal symptoms and submitted to detailed intestinal absorption tests and jejunal biopsy before and after the institution of Clofazimine therapy. Fifteen patients were administered 100 mg orally daily for 3 months, while six patients with ENL received 300 mg of the drug for 6 weeks initially and then 100 mg daily. Mild diarrhoea and abdominal symptoms occurred in four patients, fecal fat excretion increased in one patient but Schilling's and d-Xylose tests did not alter. No significant changes were produced by Clofazimine therapy in jejunal mucosa. Clofazimine crystals were seen in the lamina properia of one patient, the overlying mucosa was normal. No correlation was found between the abnormality in mucosal pattern, crystal deposition, absorption parameters or symptomatology and doses of drug taken.

PY - 1985 SP - 364 EP - 72 T2 - Indian journal of leprosy TI - Effect of clofazimine: detailed studies of small intestine functions. VL - 57 SN - 0254-9395 ER -