TY - JOUR KW - Antibodies, Viral KW - Antibody Specificity KW - Gels KW - Humans KW - Immunodiffusion KW - Infectious Mononucleosis KW - leprosy KW - Lupus Erythematosus, Systemic KW - Multiple Sclerosis KW - Neoplasms KW - Newcastle disease virus KW - Sepharose KW - Syphilis AU - Powell J A AU - Kano K AU - Milgrom F AB -

Specificity of antibodies to Victoria strain of Newcastle disease virus (NDV) found in infectious mononucleosis (IM) and other pathologic sera was investigated by agglutination of NDV-modified human O red blood cells, as well as by immunodiffusion and enzyme immunoassay with various preparations of the virus. These studies clearly demonstrated that the NDV antibodies are distinct from P-B or H-D antibodies. The unexpected observation that guinea pig kidney (GPK) tissues absorbed NDV antibodies allowed their classification into a group of 'GPK-positive' heterophile antibodies. The simultaneous occurrence of the NDV antibodies and H-D antibodies in IM and other diseases suggests the possibility that multiple new antigenic determinants, especially those of carbohydrate nature, may appear due to the alteration of self-antigens as a result of various pathologic processes.

BT - International archives of allergy and applied immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/3920153?dopt=Abstract DA - 1985 DO - 10.1159/000233717 IS - 4 J2 - Int. Arch. Allergy Appl. Immunol. LA - eng N2 -

Specificity of antibodies to Victoria strain of Newcastle disease virus (NDV) found in infectious mononucleosis (IM) and other pathologic sera was investigated by agglutination of NDV-modified human O red blood cells, as well as by immunodiffusion and enzyme immunoassay with various preparations of the virus. These studies clearly demonstrated that the NDV antibodies are distinct from P-B or H-D antibodies. The unexpected observation that guinea pig kidney (GPK) tissues absorbed NDV antibodies allowed their classification into a group of 'GPK-positive' heterophile antibodies. The simultaneous occurrence of the NDV antibodies and H-D antibodies in IM and other diseases suggests the possibility that multiple new antigenic determinants, especially those of carbohydrate nature, may appear due to the alteration of self-antigens as a result of various pathologic processes.

PY - 1985 SP - 336 EP - 40 T2 - International archives of allergy and applied immunology TI - Specificity of antibodies to Newcastle disease virus. VL - 76 SN - 0020-5915 ER -