TY - JOUR KW - Disease Susceptibility KW - Female KW - Genes, Recessive KW - Genetic Linkage KW - HLA Antigens KW - Humans KW - leprosy KW - Male KW - Models, Genetic KW - Pedigree AU - Haile R W AU - Iselius L AU - Fine PE AU - Morton N E AB -

Data on 72 families with multiple cases of leprosy were analyzed for a susceptibility gene linked to the HLA loci. We conducted segregation analysis with the program POINTER and identity of HLA types by descent analysis to determine the most likely mode of inheritance. We then conducted linkage analysis with the program LINKAS, first assuming linkage equilibrium and then allowing for linkage disequilibrium and etiological heterogeneity. Segregation results suggest a recessive mode of inheritance, especially for the tuberculoid forms of leprosy. The linkage results, limited to tuberculoid forms and assuming a recessive model, suggest a hypothesis of loose linkage with no unlinked locus. When an additive model is assumed, the best fit is obtained with a hypothesis of complete linkage (theta = 0.0) with heterogeneity. We currently favor the additive model as the more plausible one.

BT - Human heredity C1 - http://www.ncbi.nlm.nih.gov/pubmed/3972424?dopt=Abstract DA - 1985 DO - 10.1159/000153514 IS - 1 J2 - Hum. Hered. LA - eng N2 -

Data on 72 families with multiple cases of leprosy were analyzed for a susceptibility gene linked to the HLA loci. We conducted segregation analysis with the program POINTER and identity of HLA types by descent analysis to determine the most likely mode of inheritance. We then conducted linkage analysis with the program LINKAS, first assuming linkage equilibrium and then allowing for linkage disequilibrium and etiological heterogeneity. Segregation results suggest a recessive mode of inheritance, especially for the tuberculoid forms of leprosy. The linkage results, limited to tuberculoid forms and assuming a recessive model, suggest a hypothesis of loose linkage with no unlinked locus. When an additive model is assumed, the best fit is obtained with a hypothesis of complete linkage (theta = 0.0) with heterogeneity. We currently favor the additive model as the more plausible one.

PY - 1985 SP - 43 EP - 52 T2 - Human heredity TI - Segregation and linkage analyses of 72 leprosy pedigrees. VL - 35 SN - 0001-5652 ER -