TY - JOUR
KW - Animals
KW - Antibodies, Bacterial
KW - Cercopithecidae
KW - Cercopithecus aethiops
KW - Disease Models, Animal
KW - Disease Susceptibility
KW - Female
KW - Haplorhini
KW - leprosy
KW - Lymphocyte Activation
KW - Macaca mulatta
KW - Male
KW - Mycobacterium leprae
KW - Saimiri
KW - Species Specificity
AU - Wolf R H
AU - Gormus B J
AU - Martin L N
AU - Baskin G B
AU - Walsh G P
AU - Meyers W M
AU - Binford C H
AB - <p>Eleven mangabey monkeys inoculated with Mycobacterium leprae developed lepromatous-type leprosy. Nine of the mangabeys were inoculated with M. leprae isolated from a mangabey with naturally acquired lepromatous leprosy. Immune function was depressed in some of these animals after dissemination of the disease. Two mangabeys developed lepromatous leprosy after inoculation with human M. leprae passaged in an armadillo. Three rhesus and three African green monkeys inoculated with mangabey-derived M. leprae also developed lepromatous leprosy. Mangabeys may be the first reported nonhuman primate model for the study of leprosy. Rhesus and African green monkeys may also prove to be reproducibly susceptible to the disease.</p>
BT - Science (New York, N.Y.)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3917577?dopt=Abstract
DA - 1985 Feb 01
DO - 10.1126/science.3917577
IS - 4686
J2 - Science
LA - eng
N2 - <p>Eleven mangabey monkeys inoculated with Mycobacterium leprae developed lepromatous-type leprosy. Nine of the mangabeys were inoculated with M. leprae isolated from a mangabey with naturally acquired lepromatous leprosy. Immune function was depressed in some of these animals after dissemination of the disease. Two mangabeys developed lepromatous leprosy after inoculation with human M. leprae passaged in an armadillo. Three rhesus and three African green monkeys inoculated with mangabey-derived M. leprae also developed lepromatous leprosy. Mangabeys may be the first reported nonhuman primate model for the study of leprosy. Rhesus and African green monkeys may also prove to be reproducibly susceptible to the disease.</p>
PY - 1985
SP - 529
EP - 31
T2 - Science (New York, N.Y.)
TI - Experimental leprosy in three species of monkeys.
VL - 227
SN - 0036-8075
ER -