TY - JOUR
KW - Animals
KW - Dapsone
KW - Drug Resistance, Microbial
KW - Foot
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Mice
KW - Mycobacterium leprae
KW - Serotonin
AU - Balakrishnan S
AU - Mester L
AU - Venkataramaniah H N
AU - Bhatia V N
AB - <p>Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3908578?dopt=Abstract
CN - Infolep Library - available
DA - 1985 Apr-Jun
IS - 2
J2 - Indian J Lepr
LA - eng
N2 - <p>Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.</p>
PY - 1985
SP - 323
EP - 8
T2 - Indian journal of leprosy
TI - Mouse foot-pad studies with M. leprae--effect of desoxy fructo serotonin (DFS) and related compounds.
VL - 57
SN - 0254-9395
ER -