TY - JOUR
KW - Animals
KW - Edema
KW - Erythema
KW - Female
KW - Granuloma
KW - Inflammation
KW - leprosy
KW - Macrophages
KW - Mice
KW - Mice, Nude
KW - Muscles
KW - Mycobacterium leprae
KW - Nasal Cavity
KW - Nasal Mucosa
AU - Chehl S
AU - Job C K
AU - Hastings R C
AB - <p>Nude mice in groups of 10 were exposed to M. leprae by subcutaneous injection and topically through the nose, lungs, mouth, stomach and skin, broken and unbroken. Animals injected subcutaneously and those topically exposed to M. leprae through the nose developed localized disease which in the course of time became generalized. The nose seems to be the site of entry of M. leprae in this model. To the extent that these results can be generalized to humans exposed to M. leprae, it would seem that leprosy bacilli impact topically on the nasal mucosa or are inoculated subcutaneously.</p>
BT - The American journal of tropical medicine and hygiene
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3914846?dopt=Abstract
DA - 1985 Nov
DO - 10.4269/ajtmh.1985.34.1161
IS - 6
J2 - Am. J. Trop. Med. Hyg.
LA - eng
N2 - <p>Nude mice in groups of 10 were exposed to M. leprae by subcutaneous injection and topically through the nose, lungs, mouth, stomach and skin, broken and unbroken. Animals injected subcutaneously and those topically exposed to M. leprae through the nose developed localized disease which in the course of time became generalized. The nose seems to be the site of entry of M. leprae in this model. To the extent that these results can be generalized to humans exposed to M. leprae, it would seem that leprosy bacilli impact topically on the nasal mucosa or are inoculated subcutaneously.</p>
PY - 1985
SP - 1161
EP - 6
T2 - The American journal of tropical medicine and hygiene
TI - Transmission of leprosy in nude mice.
VL - 34
SN - 0002-9637
ER -