TY - JOUR
KW - Adjuvants, Immunologic
KW - Adult
KW - BCG Vaccine
KW - Cimetidine
KW - Clinical Trials as Topic
KW - Double-Blind Method
KW - Female
KW - Humans
KW - Lepromin
KW - leprosy
KW - Leukocyte Count
KW - Lymphocyte Activation
KW - Lymphocytes
KW - Male
KW - Middle Aged
KW - Phytohemagglutinins
KW - Random Allocation
KW - Skin Tests
KW - Tuberculin Test
AU - Brown A E
AU - Nelson K E
AU - Makonkawkeyoon S
AU - Vithayasai V
AU - Scollard D M
AU - Bullock W E
AB - <p>To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant "booster" response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3910745?dopt=Abstract
DA - 1985 Dec
IS - 4
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>To test the capacity of cimetidine to enhance cellular immunity in patients with lepromatous leprosy (LL), cimetidine was given for one month to 29 inactive LL patients and 3 active LL patients. Immune function was monitored with skin tests (lepromin, PPD, candida, and trichopytin), lymphocyte transformation tests (phytohemagglutinin, BCG, and Dharmendra lepromin), and quantitation of peripheral blood lymphocyte subpopulations. A small but significant "booster" response to PPD was the only change observed in the study of patients with inactive disease, and leprosy-related reactions did not occur. In the few active LL patients studied, neither immune enhancement nor leprosy-related reactions were observed. The results of this investigation suggest that cimetidine can be used safely in patients with inactive lepromatous leprosy.</p>
PY - 1985
SP - 559
EP - 64
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - A study of the immunological effects of cimetidine in patients with lepromatous leprosy.
VL - 53
SN - 0148-916X
ER -