TY - JOUR KW - Animals KW - B-Lymphocytes KW - BCG Vaccine KW - Hindlimb KW - Hypersensitivity, Delayed KW - Immunization, Passive KW - leprosy KW - Mice KW - Mice, Inbred CBA KW - T-Lymphocytes KW - Time Factors KW - Vaccination AU - Lowe C AU - Brett S J AU - Rees R J AB -

Cells were transferred from mice intradermally vaccinated with killed Mycobacterium leprae to sublethally irradiated recipients. Unseparated cells from lymph nodes or spleens of M. leprae vaccinated mice were found to cause significant inhibition of the growth of a subsequent M. leprae challenge in mouse footpads for up to 26 weeks after vaccination. Vaccination with live BCG and cells transferred from BCG-vaccinated mice caused no significant inhibition of M. leprae growth in mouse footpads. Cell separation into fractions containing predominantly B and T lymphocytes showed that the inhibition of growth was due to M. leprae-sensitized T lymphocytes. M. leprae vaccinated mice were also skin tested with soluble M. leprae antigen and showed maximum delayed hypersensitivity responses 4 weeks after vaccination.

BT - Clinical and experimental immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/3876183?dopt=Abstract DA - 1985 Aug IS - 2 J2 - Clin. Exp. Immunol. LA - eng N2 -

Cells were transferred from mice intradermally vaccinated with killed Mycobacterium leprae to sublethally irradiated recipients. Unseparated cells from lymph nodes or spleens of M. leprae vaccinated mice were found to cause significant inhibition of the growth of a subsequent M. leprae challenge in mouse footpads for up to 26 weeks after vaccination. Vaccination with live BCG and cells transferred from BCG-vaccinated mice caused no significant inhibition of M. leprae growth in mouse footpads. Cell separation into fractions containing predominantly B and T lymphocytes showed that the inhibition of growth was due to M. leprae-sensitized T lymphocytes. M. leprae vaccinated mice were also skin tested with soluble M. leprae antigen and showed maximum delayed hypersensitivity responses 4 weeks after vaccination.

PY - 1985 SP - 336 EP - 42 T2 - Clinical and experimental immunology TI - Adoptive cell transfer of resistance to Mycobacterium leprae infections in mice. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1577294/pdf/clinexpimmunol00131-0120.pdf VL - 61 SN - 0009-9104 ER -