Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice.
BT - Transactions of the Royal Society of Tropical Medicine and Hygiene C1 - http://www.ncbi.nlm.nih.gov/pubmed/382465?dopt=Abstract DA - 1979 DO - 10.1016/0035-9203(79)90215-3 IS - 2 J2 - Trans. R. Soc. Trop. Med. Hyg. LA - eng N2 -Differing patterns of Mycobacterium lepraemurium infection in inbred strains of mice are of interest as a model system for studying mycobacterial infections of man, e.g. M. leprae, which present with a spectrum of clinical disease. In vitro, macrophages from both resistant (C57B1) and susceptible (BALB/c) inbred strains of mice can be shown to be equally effective in controlling multiplication of M. lepraemurium. Experiments presented here show that in vivo, the potential mechanisms of macrophage-mediated immunity are suppressed in the susceptible (BALB/c) strain of mouse by a soluble factor(s) present in the serum and the peritoneal fluid of infected mice.
PY - 1979 SP - 212 EP - 5 T2 - Transactions of the Royal Society of Tropical Medicine and Hygiene TI - Serum from infected mice suppresses macrophage-mediated immunity in Mycobacterium lepraemurium infection: a model for imparied macrophage immunity in human leprosy. VL - 73 SN - 0035-9203 ER -