Recommendations for future research in leprosy include (i) cultivation of M. leprae in vitro; (ii) genetic control of susceptibility, including twin studies and HLA typing; (iii) precise antigenic analysis of M. leprae; (iv) mechanisms involved in the macrophage response to mycobacterial infections; (v) more use of experimental models such as normal mice infected with M. lepraemurium; (vi) reassessment of the protection afforded by BCG; (vii) assessment of protection afforded by killed (armadillo) M. leprae vaccine; (viii) pathogenesis of erythema nodosum leprosum including a study of the effect of thalidomide; and (ix) development of in vitro systems for drug sensitivity testing.
BT - Clinical and experimental immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/380853?dopt=Abstract DA - 1979 Apr IS - 1 J2 - Clin. Exp. Immunol. LA - eng N2 -Recommendations for future research in leprosy include (i) cultivation of M. leprae in vitro; (ii) genetic control of susceptibility, including twin studies and HLA typing; (iii) precise antigenic analysis of M. leprae; (iv) mechanisms involved in the macrophage response to mycobacterial infections; (v) more use of experimental models such as normal mice infected with M. lepraemurium; (vi) reassessment of the protection afforded by BCG; (vii) assessment of protection afforded by killed (armadillo) M. leprae vaccine; (viii) pathogenesis of erythema nodosum leprosum including a study of the effect of thalidomide; and (ix) development of in vitro systems for drug sensitivity testing.
PY - 1979 SP - 1 EP - 7 T2 - Clinical and experimental immunology TI - Research in leprosy. A report of a committee set up by the medical research council to study future prospects. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1537685/pdf/clinexpimmunol00205-0009.pdf VL - 36 SN - 0009-9104 ER -