TY - JOUR
KW - Adult
KW - Clofazimine
KW - Dapsone
KW - Drug Therapy, Combination
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Male
KW - Middle Aged
KW - Rifampin
AU - Bhate R D
AU - Gupta C M
AU - Chattopadhyay S P
AU - Singh I P
AB - <p>Eighty paucibacillary leprosy cases were randomly put on two different multidrug regimens for 6 months followed by dapsone monotherapy. Regimen I was according to WHO (1982) recommendations consisting of Dapsone and six once a month rifampicin. In regimen II in addition to above two constituents, clofazimine was added 100 mg on alternate days. Dapsone thereafter was continued in both the regimens upto one year. The efficacy, acceptability and side effects of multidrug regimens were observed for a period of one year. Histopathological assessment was done on completion of multidrug therapy in all cases. A comparative evaluation of effect of two multidrug regimens in paucibacillary leprosy patients is reported. Addition of clofazimine over WHO (1982) recommended regimen appears to have no added benefit. The duration of WHO (1982) recommended regimens was found to be inadequate in many cases.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3805797?dopt=Abstract
CN - Infolep Library - available
DA - 1986 Apr-Jun
IS - 2
J2 - Indian J Lepr
LA - eng
N2 - <p>Eighty paucibacillary leprosy cases were randomly put on two different multidrug regimens for 6 months followed by dapsone monotherapy. Regimen I was according to WHO (1982) recommendations consisting of Dapsone and six once a month rifampicin. In regimen II in addition to above two constituents, clofazimine was added 100 mg on alternate days. Dapsone thereafter was continued in both the regimens upto one year. The efficacy, acceptability and side effects of multidrug regimens were observed for a period of one year. Histopathological assessment was done on completion of multidrug therapy in all cases. A comparative evaluation of effect of two multidrug regimens in paucibacillary leprosy patients is reported. Addition of clofazimine over WHO (1982) recommended regimen appears to have no added benefit. The duration of WHO (1982) recommended regimens was found to be inadequate in many cases.</p>
PY - 1986
SP - 244
EP - 50
T2 - Indian journal of leprosy
TI - Experience with multidrug therapy in paucibacillary leprosy.
VL - 58
SN - 0254-9395
ER -