Morphological and histochemical characteristics of reverse reactions in M. leprae-infected armadillos are reviewed. The reverse reactions develop in generalized lepromatous disease and are characterized by a dramatic decrease in mycobacterial macrophage load and the appearance of lymphocytes, epithelioid and giant multinuclear cells with peripheral nucleus distribution. Histochemical investigation has shown a decrease in the activity of redox enzymes and alpha-naphthyl acetate esterase and an increase in beta-glucuronidase activity. The reverse reactions in the liver are accompanied by hepatic granuloma and hepatocyte destruction.
BT - Biulleten' eksperimental'noi biologii i meditsiny C1 - http://www.ncbi.nlm.nih.gov/pubmed/3828527?dopt=Abstract DA - 1987 Mar IS - 3 J2 - Biull Eksp Biol Med LA - rus N2 -Morphological and histochemical characteristics of reverse reactions in M. leprae-infected armadillos are reviewed. The reverse reactions develop in generalized lepromatous disease and are characterized by a dramatic decrease in mycobacterial macrophage load and the appearance of lymphocytes, epithelioid and giant multinuclear cells with peripheral nucleus distribution. Histochemical investigation has shown a decrease in the activity of redox enzymes and alpha-naphthyl acetate esterase and an increase in beta-glucuronidase activity. The reverse reactions in the liver are accompanied by hepatic granuloma and hepatocyte destruction.
PY - 1987 SP - 376 EP - 80 T2 - Biulleten' eksperimental'noi biologii i meditsiny TI - [Histochemical study of reverse reactions in experimental leprosy in armadillos]. VL - 103 SN - 0365-9615 ER -