The lymphocyte hyporesponsiveness to M. leprae of patients with active lepromatous leprosy has been well described. This immune defect is less well understood in terms of its time of origin, possible reversibility and specificity. To further examine the persistence and specificity of this abnormality, lymphocyte transformation tests of 93 leprosy patients to lepromin, BCG and PHA were studied. Among lepromatous patients, a decreased response to M. leprae was seen, whether the disease was active or inactive. Decreased responses to BCG were found in lepromatous patients with active disease, but not in those with inactive disease. The duration of patient symptoms was not associated with differences in LTT responses among the active lepromatous patients.
BT - The Southeast Asian journal of tropical medicine and public health C1 - http://www.ncbi.nlm.nih.gov/pubmed/3738597?dopt=Abstract DA - 1986 Mar IS - 1 J2 - Southeast Asian J. Trop. Med. Public Health LA - eng N2 -The lymphocyte hyporesponsiveness to M. leprae of patients with active lepromatous leprosy has been well described. This immune defect is less well understood in terms of its time of origin, possible reversibility and specificity. To further examine the persistence and specificity of this abnormality, lymphocyte transformation tests of 93 leprosy patients to lepromin, BCG and PHA were studied. Among lepromatous patients, a decreased response to M. leprae was seen, whether the disease was active or inactive. Decreased responses to BCG were found in lepromatous patients with active disease, but not in those with inactive disease. The duration of patient symptoms was not associated with differences in LTT responses among the active lepromatous patients.
PY - 1986 SP - 104 EP - 10 T2 - The Southeast Asian journal of tropical medicine and public health TI - Lymphocyte transformation in lepromatous leprosy: a study of the influence of disease activity and symptom duration. VL - 17 SN - 0125-1562 ER -