For an autosomal recessive disease, a statistical procedure is developed for detecting nonrandom segregation of marker haplotypes from an unaffected parent to affected children, specifically for the case when the alternative hypothesis of linkage between the disease and marker loci is postulated. The test procedure is locally most powerful and, depending on family size and number of families sampled, any one of the three test statistics proposed can be used. An application of this procedure provides evidence of linkage between tuberculoid leprosy and HLA.
BT - Genetic epidemiology C1 - http://www.ncbi.nlm.nih.gov/pubmed/3692136?dopt=Abstract DA - 1987 DO - 10.1002/gepi.1370040507 IS - 5 J2 - Genet. Epidemiol. LA - eng N2 -For an autosomal recessive disease, a statistical procedure is developed for detecting nonrandom segregation of marker haplotypes from an unaffected parent to affected children, specifically for the case when the alternative hypothesis of linkage between the disease and marker loci is postulated. The test procedure is locally most powerful and, depending on family size and number of families sampled, any one of the three test statistics proposed can be used. An application of this procedure provides evidence of linkage between tuberculoid leprosy and HLA.
PY - 1987 SP - 387 EP - 91 T2 - Genetic epidemiology TI - Further tests of nonrandom segregation with special reference to linkage. VL - 4 SN - 0741-0395 ER -