TY - JOUR KW - Adolescent KW - Adult KW - Age Factors KW - Aged KW - Cell Count KW - Clinical Trials as Topic KW - Clofazimine KW - Dapsone KW - Female KW - Humans KW - leprosy KW - Male KW - Middle Aged KW - Mycobacterium leprae KW - Rifampin KW - Sex Factors KW - Skin KW - Statistics as Topic AB -

Interrelationships among six patient characteristics recorded upon entry into the trial were analyzed for 67 patients with lepromatous and near-lepromatous leprosy admitted into two chemotherapy trials. Sex was found to be significantly associated with age and with the histopathologic classification; disproportionately large numbers of older patients and of patients classified as borderline-lepromatous (BL) were males. Classifications of the disease process by clinical and histopathologic criteria were closely associated, but many patients classified BL on histopathological grounds were classified fully lepromatous by the clinical criteria. Measurements of the number of Mycobacterium leprae in the patients made by three methods were also significantly correlated. No significant correlations were found between either classification of the disease process on the one hand, and any of the measurements of the numbers of organisms on the other.

BT - The American journal of tropical medicine and hygiene C1 - http://www.ncbi.nlm.nih.gov/pubmed/362951?dopt=Abstract DA - 1978 Sep DO - 10.4269/ajtmh.1978.27.1015 IS - 5 J2 - Am. J. Trop. Med. Hyg. LA - eng N2 -

Interrelationships among six patient characteristics recorded upon entry into the trial were analyzed for 67 patients with lepromatous and near-lepromatous leprosy admitted into two chemotherapy trials. Sex was found to be significantly associated with age and with the histopathologic classification; disproportionately large numbers of older patients and of patients classified as borderline-lepromatous (BL) were males. Classifications of the disease process by clinical and histopathologic criteria were closely associated, but many patients classified BL on histopathological grounds were classified fully lepromatous by the clinical criteria. Measurements of the number of Mycobacterium leprae in the patients made by three methods were also significantly correlated. No significant correlations were found between either classification of the disease process on the one hand, and any of the measurements of the numbers of organisms on the other.

PY - 1978 SP - 1015 EP - 8 T2 - The American journal of tropical medicine and hygiene TI - A statistical analysis of two chemotherapy trials in lepromatous leprosy. II. Interactions among patient variables. VL - 27 SN - 0002-9637 ER -