TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Antibodies, Antinuclear
KW - Antibody Specificity
KW - Cross Reactions
KW - Cryoglobulins
KW - Diagnosis, Differential
KW - Female
KW - Fluorescent Antibody Technique
KW - Humans
KW - leprosy
KW - Male
KW - Middle Aged
KW - Prospective Studies
AU - Miller R A
AU - Wener M H
AU - Harnisch JP
AU - Gilliland B C
AB - <p>Sera from 46 consecutive patients with leprosy were collected and tested against an extensive panel of defined nuclear antigens. Antinuclear antibodies (ANA) were present in 16% of patients, but the titer was uniformly low and there was no consistent fluorescence pattern. None of the ANA positive sera contained antibodies which reacted with native DNA, or which were directed against histones, centromeres, SSB, Sm, or ribonucleoprotein. These more specific autoantibody assays thus retained their clinical utility in the differential diagnosis of rheumatologic complaints in patients with leprosy.</p>
BT - The Journal of rheumatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3553585?dopt=Abstract
DA - 1987 Feb
IS - 1
J2 - J. Rheumatol.
LA - eng
N2 - <p>Sera from 46 consecutive patients with leprosy were collected and tested against an extensive panel of defined nuclear antigens. Antinuclear antibodies (ANA) were present in 16% of patients, but the titer was uniformly low and there was no consistent fluorescence pattern. None of the ANA positive sera contained antibodies which reacted with native DNA, or which were directed against histones, centromeres, SSB, Sm, or ribonucleoprotein. These more specific autoantibody assays thus retained their clinical utility in the differential diagnosis of rheumatologic complaints in patients with leprosy.</p>
PY - 1987
SP - 108
EP - 10
T2 - The Journal of rheumatology
TI - The limited spectrum of antinuclear antibodies in leprosy.
VL - 14
SN - 0315-162X
ER -