Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.
BT - Medical hypotheses C1 - http://www.ncbi.nlm.nih.gov/pubmed/3488493?dopt=Abstract DA - 1986 Jun DO - 10.1016/0306-9877(86)90120-9 IS - 2 J2 - Med. Hypotheses LA - eng N2 -Neural fibrosis in leprosy, the disease caused by the obligate intracellular bacterium, Mycobacterium leprae, is closely related to the cell-mediated immune response to this microorganism. The fibrosis appears to be due to soluble mediators released by the immune effector cells. Interleukin 1, a macrophage product that stimulates fibroblast migration, proliferation and synthetic activity, possesses the requisite properties to qualify for such a mediator.
PY - 1986 SP - 143 EP - 50 T2 - Medical hypotheses TI - Interleukin 1--a possible mediator of neural fibrosis in leprosy. VL - 20 SN - 0306-9877 ER -