Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxidase technique. In both mangabey and human lepromatous granulomas OKT4 (or Leu 3a) and Leu 2a cells were scattered among macrophages with greater numbers of Leu 2a as compared with OKT4 (or Leu 3a) cells. The results suggest that from an immunopathological standpoint experimental leprosy in mangabeys will provide a suitable model for the investigation of the pathogenesis of human lepromatous leprosy and for the evaluation of new antileprosy vaccines.
BT - Clinical and experimental immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/3491704?dopt=Abstract DA - 1986 Aug IS - 2 J2 - Clin. Exp. Immunol. LA - eng N2 -Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxidase technique. In both mangabey and human lepromatous granulomas OKT4 (or Leu 3a) and Leu 2a cells were scattered among macrophages with greater numbers of Leu 2a as compared with OKT4 (or Leu 3a) cells. The results suggest that from an immunopathological standpoint experimental leprosy in mangabeys will provide a suitable model for the investigation of the pathogenesis of human lepromatous leprosy and for the evaluation of new antileprosy vaccines.
PY - 1986 SP - 260 EP - 4 T2 - Clinical and experimental immunology TI - In situ characterization of T lymphocyte subpopulations in leprosy in the mangabey monkey. UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542319/pdf/clinexpimmunol00119-0048.pdf VL - 65 SN - 0009-9104 ER -