TY - JOUR
KW - Antibodies, Monoclonal
KW - Antigens, Differentiation, T-Lymphocyte
KW - Humans
KW - Immunity, Cellular
KW - Lepromin
KW - leprosy
KW - Lymphocyte Activation
KW - T-Lymphocytes
KW - Trypsin
AU - Muthukkaruppan V
AU - Chakkalath H R
AU - James M M
AB - <p>By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.</p>
BT - Immunology letters
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3499387?dopt=Abstract
DA - 1987 Jul
DO - 10.1016/0165-2478(87)90025-3
IS - 3
J2 - Immunol. Lett.
LA - eng
N2 - <p>By using an indirect immunofluorescence technique with OKT3 and OKT11 monoclonal antibodies, the percentage of CD2 positive cells was found to be reduced in the peripheral blood of bacterial index positive lepromatous leprosy patients; however, in these patients, CD3 positive cells were at the normal level. Further CD2 positive cells attained the normal proportion in lepromatous patients when mycobacterial load was reduced. Both CD2 and CD3 receptors were expressed at the normal level in tuberculoid leprosy patients. Prior treatment of peripheral blood mononuclear cells from healthy controls with Mycobacterium leprae significantly decreased the percentage of CD2 but not CD3 positive cells. Such a modulation of CD2 on T cells also resulted in blocking the lymphoproliferative response induced by mitogen and antigen. These results suggest that there is a strong correlation between CD2 modulation and immunologic unresponsiveness in leprosy.</p>
PY - 1987
SP - 199
EP - 204
T2 - Immunology letters
TI - Immunologic unresponsiveness in leprosy is mediated by modulation of E-receptor.
VL - 15
SN - 0165-2478
ER -