TY - JOUR
KW - Antigens, Bacterial
KW - Cell Count
KW - Humans
KW - leprosy
KW - Lymphocyte Activation
KW - Mycobacterium leprae
KW - Rosette Formation
KW - T-Lymphocytes
AU - Nath I
AU - Curtis J
AU - Sharma A K
AU - Talwar G P
AB - <p>The effect of treatment and mycobacterial load on circulating T-cell numbers and their functional ability was investigated in forty-one patients with leprosy. Both early binding T cells and their responses to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) were profoundly and uniformly depressed in untreated, and partially treated, bacilleferous lepromatous leprosy (LL) patients as compared with normal subjects and tuberculoid patients. On elimination of mycobacteria, subsequent to chemotherapy, LL patients regain normality in T-cell numbers and their functions. On the other hand, the specific response of lymphocytes to M. leprae did not alter with decrease in mycobacterial load. It appears that the decrease in T-cell numbers and the deficit in their mitogenic potential is a secondary consequence of disease and is related to the antigenic load in patients with lepromatous leprosy.</p>
BT - Clinical and experimental immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/338218?dopt=Abstract
DA - 1977 Sep
IS - 3
J2 - Clin. Exp. Immunol.
LA - eng
N2 - <p>The effect of treatment and mycobacterial load on circulating T-cell numbers and their functional ability was investigated in forty-one patients with leprosy. Both early binding T cells and their responses to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) were profoundly and uniformly depressed in untreated, and partially treated, bacilleferous lepromatous leprosy (LL) patients as compared with normal subjects and tuberculoid patients. On elimination of mycobacteria, subsequent to chemotherapy, LL patients regain normality in T-cell numbers and their functions. On the other hand, the specific response of lymphocytes to M. leprae did not alter with decrease in mycobacterial load. It appears that the decrease in T-cell numbers and the deficit in their mitogenic potential is a secondary consequence of disease and is related to the antigenic load in patients with lepromatous leprosy.</p>
PY - 1977
SP - 393
EP - 400
T2 - Clinical and experimental immunology
TI - Circulating T-cell numbers and their mitogenic potential in leprosy--correlation with mycobacterial load.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1541056/pdf/clinexpimmunol00235-0035.pdf
VL - 29
SN - 0009-9104
ER -