TY - JOUR
KW - Adult
KW - Biopsy, Needle
KW - Female
KW - Granuloma
KW - Humans
KW - leprosy
KW - Male
KW - Skin
AU - Cree I A
AU - Srinivasan T
AU - Krishnan S A
AU - Gardiner C A
AU - Mehta J
AU - Fisher C A
AU - Beck J S
AB - <p>The variability of three commonly used histological parameters in leprosy histology was examined within and between lesions on individual patients by taking two biopsies, either from opposing edges of the same lesion or from the edge of two separate lesions. There was little variation in granuloma fraction (GF), bacterial index (BI), or histological classification on the Ridley-Jopling scale between biopsies from opposing edges of the same lesion, but there was considerable variation in the GF between biopsies from the edge of different lesions. A lesser degree of variation was seen in the BI between different lesions, and there was little difference in histological classification between established lesions. Thus, it appears that local factors influence the size of the leprosy granuloma, but its histological composition and bacterial load are determined systemically.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3411168?dopt=Abstract
DA - 1988 Jun
IS - 2
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>The variability of three commonly used histological parameters in leprosy histology was examined within and between lesions on individual patients by taking two biopsies, either from opposing edges of the same lesion or from the edge of two separate lesions. There was little variation in granuloma fraction (GF), bacterial index (BI), or histological classification on the Ridley-Jopling scale between biopsies from opposing edges of the same lesion, but there was considerable variation in the GF between biopsies from the edge of different lesions. A lesser degree of variation was seen in the BI between different lesions, and there was little difference in histological classification between established lesions. Thus, it appears that local factors influence the size of the leprosy granuloma, but its histological composition and bacterial load are determined systemically.</p>
PY - 1988
SP - 296
EP - 301
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Reproducibility of histology in leprosy lesions.
VL - 56
SN - 0148-916X
ER -