TY - JOUR KW - Animals KW - Antibodies, Bacterial KW - Antigen-Antibody Complex KW - Antigens, Bacterial KW - Immune Tolerance KW - Immunity, Cellular KW - leprosy KW - Leukocyte Count KW - Lymphocyte Activation KW - Lymphocytes KW - Mice KW - Mycobacterium leprae AU - Vaishnavi C AU - Kaur S AU - Kumar B AU - Ganguly N K AB -

Swiss albino mice (normal as well as thymectomised and irradiated were inoculated into the footpads with Mycobacterium leprae and divided into two main phases of study. Phase I comprised of animals not given preformed immune complexes (IC). Uninfected controls were however included. Phase II consisted of animals given in vitro prepared IC at zero day period (OdIC), three month period (3mIC) or six month period (6mIC) to both uninfected and infected groups. Splenic lymphocytes were isolated to quantify T and B cells and their responses to M. leprae antigen and four different mitogens. Significant decrease in T cell counts and blast transformation was seen in the M. leprae infected animals which were also administered with immune complexes. Immunosuppression by IC was therefore seen to be enhanced in the presence of M. leprae infection.

BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/3330555?dopt=Abstract CN - Infolep Library - available DA - 1987 Oct-Dec IS - 4 J2 - Indian J Lepr LA - eng N2 -

Swiss albino mice (normal as well as thymectomised and irradiated were inoculated into the footpads with Mycobacterium leprae and divided into two main phases of study. Phase I comprised of animals not given preformed immune complexes (IC). Uninfected controls were however included. Phase II consisted of animals given in vitro prepared IC at zero day period (OdIC), three month period (3mIC) or six month period (6mIC) to both uninfected and infected groups. Splenic lymphocytes were isolated to quantify T and B cells and their responses to M. leprae antigen and four different mitogens. Significant decrease in T cell counts and blast transformation was seen in the M. leprae infected animals which were also administered with immune complexes. Immunosuppression by IC was therefore seen to be enhanced in the presence of M. leprae infection.

PY - 1987 SP - 452 EP - 61 T2 - Indian journal of leprosy TI - Role of immune complexes in alteration of lymphocyte subpopulation numbers and functions in experimental leprosy. VL - 59 SN - 0254-9395 ER -