The plasma DDS clearance rates and the acetylation rates of Sulphadimidine were studied in a group of 30 leprosy patients comprising of 17 non-responders and 13 responders to DDS treatment. No differences in the acetylator type or in the plasma DDS clearance were seen between the responders and non-responders. Acetylation rate did not bear any relation to the plasma clearance of DDS in the non-responders. The findings indicate that the resistance to DDS therapy in these patients is not related to any abnormal metabolic disposition of DDS.
BT - Leprosy in India C1 - http://www.ncbi.nlm.nih.gov/pubmed/330945?dopt=Abstract CN - Infolep Library - available DA - 1977 Jan IS - 1 J2 - Lepr India LA - eng N2 -The plasma DDS clearance rates and the acetylation rates of Sulphadimidine were studied in a group of 30 leprosy patients comprising of 17 non-responders and 13 responders to DDS treatment. No differences in the acetylator type or in the plasma DDS clearance were seen between the responders and non-responders. Acetylation rate did not bear any relation to the plasma clearance of DDS in the non-responders. The findings indicate that the resistance to DDS therapy in these patients is not related to any abnormal metabolic disposition of DDS.
PY - 1977 SP - 59 EP - 64 T2 - Leprosy in India TI - Blood DDS levels and acetylation rates of sulphadimidine in leprosy patients. VL - 49 SN - 0024-1024 ER -