TY - JOUR KW - Administration, Topical KW - Animals KW - Aqueous Humor KW - Chlorobutanol KW - Ciliary Body KW - Cornea KW - Dimethyl Sulfoxide KW - Drug Administration Schedule KW - Drug Combinations KW - Iris KW - Keratitis KW - Lanolin KW - leprosy KW - Mineral Oil KW - Mycobacterium leprae KW - Ointments KW - Petrolatum KW - Pharmaceutical Vehicles KW - Polyethylene Glycols KW - Rabbits KW - Rifampin KW - Uveal Diseases AU - Feldman M F AU - Moses R A AB -

We tested the corneal penetration of rifampin in four vehicles: dimethylsulfoxide, polyethylene glycol, an ocular lubricant, and as rifampin ointment. We measured drug concentrations in the aqueous humor in rabbits after topical instillation of 1 and 2.5% rifampin according to two dosage schedules. Drug concentrations in the aqueous humor were bactericidal to Mycobacterium leprae. Since leprosy of the cornea, iris, and ciliary body may develop despite standard systemic bacteriostatic treatment, treatment of leprotic involvement of the anterior eye may be enhanced by intensive topical application of rifampin.

BT - American journal of ophthalmology C1 - http://www.ncbi.nlm.nih.gov/pubmed/326055?dopt=Abstract DA - 1977 Jun DO - 10.1016/0002-9394(77)90915-1 IS - 6 J2 - Am. J. Ophthalmol. LA - eng N2 -

We tested the corneal penetration of rifampin in four vehicles: dimethylsulfoxide, polyethylene glycol, an ocular lubricant, and as rifampin ointment. We measured drug concentrations in the aqueous humor in rabbits after topical instillation of 1 and 2.5% rifampin according to two dosage schedules. Drug concentrations in the aqueous humor were bactericidal to Mycobacterium leprae. Since leprosy of the cornea, iris, and ciliary body may develop despite standard systemic bacteriostatic treatment, treatment of leprotic involvement of the anterior eye may be enhanced by intensive topical application of rifampin.

PY - 1977 SP - 862 EP - 5 T2 - American journal of ophthalmology TI - Corneal penetration of rifampin. VL - 83 SN - 0002-9394 ER -