TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Antigen-Antibody Complex
KW - Complement C3
KW - Complement C4
KW - Erythema Nodosum
KW - Female
KW - Humans
KW - Leprosy, Borderline
KW - Leprosy, lepromatous
KW - Male
KW - Middle Aged
KW - Serum Albumin, Bovine
KW - Solubility
AU - Chakrabarty A K
AU - Kashyap A
AU - Sehgal V N
AU - Saha K
AB - <p>Serum complement activity in leprosy patients has been studied using solubilization of preformed immune complexes as an index. The solubilization capacity of sera from lepromatous patients with or without erythema nodosum leprosum (ENL) as well as from type 1 reactional patients was found markedly reduced as compared to controls. Solubilization did not improve at all in the ENL patients after remission of the reaction phase. The addition of fresh normal sera failed to bring about any significant restoration of solubilizing capacity of the deficient sera. Mycobacterium leprae sonicate significantly reduced the solubilization capacity. Our results suggest that circulating mycobacterial breakdown products possibly interfered with the capacity of the ENL patients' sera to solubilize immune complexes.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3221112?dopt=Abstract
DA - 1988 Dec
IS - 4
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>Serum complement activity in leprosy patients has been studied using solubilization of preformed immune complexes as an index. The solubilization capacity of sera from lepromatous patients with or without erythema nodosum leprosum (ENL) as well as from type 1 reactional patients was found markedly reduced as compared to controls. Solubilization did not improve at all in the ENL patients after remission of the reaction phase. The addition of fresh normal sera failed to bring about any significant restoration of solubilizing capacity of the deficient sera. Mycobacterium leprae sonicate significantly reduced the solubilization capacity. Our results suggest that circulating mycobacterial breakdown products possibly interfered with the capacity of the ENL patients' sera to solubilize immune complexes.</p>
PY - 1988
SP - 559
EP - 65
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - Solubilization of preformed immune complexes in sera of patients with type 1 and type 2 lepra reactions.
VL - 56
SN - 0148-916X
ER -