TY - JOUR KW - Cell Count KW - Erythema Nodosum KW - Humans KW - leprosy KW - Leukocyte Count KW - Skin KW - T-Lymphocytes KW - T-Lymphocytes, Helper-Inducer KW - T-Lymphocytes, Regulatory AU - Modlin R L AU - Bakke A C AU - Vaccaro S A AU - Horwitz D A AU - Taylor C R AU - Rea T H AB -

To study T lymphocytes in erythema nodosum leprosum (ENL), monoclonal antibodies were used to identify T-lymphocyte subpopulations in the blood and skin lesions of patients with ENL and patients with nonreactional lepromatous leprosy. The blood of nonreactional lepromatous patients had a lymphopenia and a proportionate reduction in pan T cells, helper-inducer, and suppressor-cytotoxic subsets, but a normal helper-suppressor ratio, as compared with controls. Patients with ENL did not differ significantly from the controls. In skin lesions, an admixture of helper and suppressor phenotypes among foamy histiocytes was found. The ENL tissue had more numerous cells of the helper-inducer phenotype and fewer of the suppressor-cytotoxic phenotype, as compared with nonreaction lepromatous tissues. In 22 patients with simultaneous examination of tissue and blood T-cell subsets, there was no correlation between tissue and blood helper-suppressor ratios, indicating that some sort of selection process brings lymphocytes into tissues from peripheral blood.

BT - Archives of dermatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/3156560?dopt=Abstract DA - 1985 Feb IS - 2 J2 - Arch Dermatol LA - eng N2 -

To study T lymphocytes in erythema nodosum leprosum (ENL), monoclonal antibodies were used to identify T-lymphocyte subpopulations in the blood and skin lesions of patients with ENL and patients with nonreactional lepromatous leprosy. The blood of nonreactional lepromatous patients had a lymphopenia and a proportionate reduction in pan T cells, helper-inducer, and suppressor-cytotoxic subsets, but a normal helper-suppressor ratio, as compared with controls. Patients with ENL did not differ significantly from the controls. In skin lesions, an admixture of helper and suppressor phenotypes among foamy histiocytes was found. The ENL tissue had more numerous cells of the helper-inducer phenotype and fewer of the suppressor-cytotoxic phenotype, as compared with nonreaction lepromatous tissues. In 22 patients with simultaneous examination of tissue and blood T-cell subsets, there was no correlation between tissue and blood helper-suppressor ratios, indicating that some sort of selection process brings lymphocytes into tissues from peripheral blood.

PY - 1985 SP - 216 EP - 9 T2 - Archives of dermatology TI - Tissue and blood T-lymphocyte subpopulations in erythema nodosum leprosum. VL - 121 SN - 0003-987X ER -