TY - JOUR KW - Continental Population Groups KW - Female KW - Gene Frequency KW - Genes KW - HLA Antigens KW - Humans KW - leprosy KW - Male KW - Sex Factors KW - Thailand AU - Greiner J AU - Schleiermacher E AU - Smith T AU - Lenhard V AU - Vogel F AB -

To investigate immunogenetics of leprosy, 205 leprosy patients (26 with tuberculoid, 57 with borderline-tuberculoid, 21 with borderline, 31 with borderline-lepromatous, and 70 with lepromatous leprosy) have been typed for HLA antigens, and compared with 183 healthy controls from the same region (Northern Thailand). There was no significant difference between the overall group of leprosy patients or the three borderline classes and the controls. The two polar forms, tuberculoid and lepromatous leprosy, however, showed significant associations: HLA-A2 is decreased and HLA-Bw17 is increased in tuberculoid leprosy; HLA-B7 is increased in lepromatous leprosy. When both polar forms are compared with each other, HLA-A2 is significantly higher, HLA-Bw40 lower in patients with lepromatous than in those with tuberculoid leprosy. The results are discussed with respect to the different immune responsiveness in the two polar forms of leprosy.

BT - Human genetics C1 - http://www.ncbi.nlm.nih.gov/pubmed/669704?dopt=Abstract DA - 1978 Jun 09 DO - 10.1007/bf00283640 IS - 2 J2 - Hum. Genet. LA - eng N2 -

To investigate immunogenetics of leprosy, 205 leprosy patients (26 with tuberculoid, 57 with borderline-tuberculoid, 21 with borderline, 31 with borderline-lepromatous, and 70 with lepromatous leprosy) have been typed for HLA antigens, and compared with 183 healthy controls from the same region (Northern Thailand). There was no significant difference between the overall group of leprosy patients or the three borderline classes and the controls. The two polar forms, tuberculoid and lepromatous leprosy, however, showed significant associations: HLA-A2 is decreased and HLA-Bw17 is increased in tuberculoid leprosy; HLA-B7 is increased in lepromatous leprosy. When both polar forms are compared with each other, HLA-A2 is significantly higher, HLA-Bw40 lower in patients with lepromatous than in those with tuberculoid leprosy. The results are discussed with respect to the different immune responsiveness in the two polar forms of leprosy.

PY - 1978 SP - 201 EP - 13 T2 - Human genetics TI - The HLA system and leprosy in Thailand. VL - 42 SN - 0340-6717 ER -