TY - JOUR KW - Adolescent KW - Adult KW - Chromosome Mapping KW - Epitopes KW - Female KW - HLA Antigens KW - Humans KW - leprosy KW - Male KW - Middle Aged KW - Thailand AU - Chiewsilp P AU - Athkambhira S AU - Chirachariyavej T AU - Bhamarapravati N AU - Entwistle C AB -

HLA-A and -B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. There were no statistically significant deviations from expected antigen distribution in patients with any of the various forms of leprosy, though the number of patients studied is relatively small. There were some interesting trends, particularly a possible decrease in the number of tuberculoid patients with A9, and an increase in the proportions of lepromatous patients with B18 and B40. Limited evidence of a genetically controlled pre-disposition to the clinical manifestations of leprosy suggests that further studies with extended typing should be carried out on the HLA haplotype segregation in informative leprosy families. These should provide a clearer indication of the relevance of the HLA (including DR) and possibly of other non-HLA loci to the possible mechanism(s) of disease susceptibility.

BT - Tissue antigens C1 - http://www.ncbi.nlm.nih.gov/pubmed/87028?dopt=Abstract DA - 1979 Mar DO - 10.1111/j.1399-0039.1979.tb00782.x IS - 3 J2 - Tissue Antigens LA - eng N2 -

HLA-A and -B locus antigens were determined in 170 unrelated patients with leprosy and 100 healthy controls. There were no statistically significant deviations from expected antigen distribution in patients with any of the various forms of leprosy, though the number of patients studied is relatively small. There were some interesting trends, particularly a possible decrease in the number of tuberculoid patients with A9, and an increase in the proportions of lepromatous patients with B18 and B40. Limited evidence of a genetically controlled pre-disposition to the clinical manifestations of leprosy suggests that further studies with extended typing should be carried out on the HLA haplotype segregation in informative leprosy families. These should provide a clearer indication of the relevance of the HLA (including DR) and possibly of other non-HLA loci to the possible mechanism(s) of disease susceptibility.

PY - 1979 SP - 186 EP - 8 T2 - Tissue antigens TI - The HLA antigens and leprosy in Thailand. VL - 13 SN - 0001-2815 ER -