Dapsone (4-4-diaminodiphenyl-sulfone) is a member of the sulfone group of antibiotics used in the treatment of leprosy and various dermatitidies and more recently employed in the management of local reactions to the bite of the brown recluse spider, Loxosceles reclusa. A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy. A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.
BT - The American journal of the medical sciences C1 - http://www.ncbi.nlm.nih.gov/pubmed/3195622?dopt=Abstract DA - 1988 Oct DO - 10.1016/s0002-9629(15)40859-6 IS - 4 J2 - Am. J. Med. Sci. LA - eng N2 -Dapsone (4-4-diaminodiphenyl-sulfone) is a member of the sulfone group of antibiotics used in the treatment of leprosy and various dermatitidies and more recently employed in the management of local reactions to the bite of the brown recluse spider, Loxosceles reclusa. A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy. A case report of the hypersensitivity syndrome occurring in a patient being treated with dapsone for a brown recluse spider bite is presented.
PY - 1988 SP - 270 EP - 1 T2 - The American journal of the medical sciences TI - Case report: dapsone hypersensitivity syndrome associated with treatment of the bite of a brown recluse spider. VL - 296 SN - 0002-9629 ER -