TY - JOUR
KW - Antigens, Bacterial
KW - Antigens, Differentiation, T-Lymphocyte
KW - Antigens, Protozoan
KW - Antigens, Surface
KW - Epidermis
KW - Histocompatibility Antigens Class II
KW - Humans
KW - Hypersensitivity, Delayed
KW - Leishmaniasis
KW - leprosy
KW - Monocytes
KW - T-Lymphocytes
AU - Kaplan G
AU - Witmer M D
AU - Nath I
AU - Steinman R M
AU - Laal S
AU - Prasad H K
AU - Sarno E N
AU - Elvers U
AU - Cohn Z A
AB - <p>The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickening. In the tuberculin response, the thickness of the epidermis sometimes doubled in 48-72 hr, and this was attributed to increases in both size and number of keratinocytes. In addition, the phenotype of the keratinocytes changed from Ia- to Ia+. Similar changes in keratinocyte Ia-antigen expression occurred in the epidermis overlying untreated tuberculoid leprosy and cutaneous leishmaniasis lesions, but not in lepromatous leprosy. We suggest that one or more epidermal growth factors may be generated in the course of a delayed immune reaction in the dermis.</p>
BT - Proceedings of the National Academy of Sciences of the United States of America
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3085090?dopt=Abstract
DA - 1986 May
DO - 10.1073/pnas.83.10.3469
IS - 10
J2 - Proc. Natl. Acad. Sci. U.S.A.
LA - eng
N2 - <p>The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous leishmaniasis. In each situation, there was a dermal accumulation of monocytes and T cells, and the epidermis exhibited thickening. In the tuberculin response, the thickness of the epidermis sometimes doubled in 48-72 hr, and this was attributed to increases in both size and number of keratinocytes. In addition, the phenotype of the keratinocytes changed from Ia- to Ia+. Similar changes in keratinocyte Ia-antigen expression occurred in the epidermis overlying untreated tuberculoid leprosy and cutaneous leishmaniasis lesions, but not in lepromatous leprosy. We suggest that one or more epidermal growth factors may be generated in the course of a delayed immune reaction in the dermis.</p>
PY - 1986
SP - 3469
EP - 73
T2 - Proceedings of the National Academy of Sciences of the United States of America
TI - Influence of delayed immune reactions on human epidermal keratinocytes.
VL - 83
SN - 0027-8424
ER -