TY - JOUR KW - Adult KW - Bilirubin KW - Cholestasis KW - Erythema Nodosum KW - Female KW - Granuloma KW - Hepatitis C KW - Hepatomegaly KW - Humans KW - Jaundice KW - leprosy KW - Liver KW - Male KW - Middle Aged KW - Splenomegaly AU - Kumar B AU - Koshy A AU - Kaur S AU - Kaur I AU - Rajwanshi A AB -

Nine patients of leprosy, 5 BL and 4 LL who developed jaundice during the course of disease were investigated. Two LL patients developed jaundice during ENL reaction. There was slight hepatomegaly in 5 patients and moderate splenomegaly in 3 only. There was significant alterations in liver enzymes and serum bilirubin in all patients. The abnormalities of the enzymes levels persisted for abnormally long periods even when the serum bilirubin had come down and the patients had become asymptomatic. Blood for HBsAg and anti-HAV IgM was negative in all the patients except one in whom HBsAg was positive. Drugs could not be implicated as the cause of jaundice, all patients maintained recovery even after restarting antileprosy drugs. The possibility of non A, non B viruses producing hepatitis during the course of disease is brought out. Course of prolonged jaundice in leprosy is compared with other diseases which could result in a similar situation.

BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/3116106?dopt=Abstract CN - Infolep Library - available DA - 1987 Apr-Jun IS - 2 J2 - Indian J Lepr LA - eng N2 -

Nine patients of leprosy, 5 BL and 4 LL who developed jaundice during the course of disease were investigated. Two LL patients developed jaundice during ENL reaction. There was slight hepatomegaly in 5 patients and moderate splenomegaly in 3 only. There was significant alterations in liver enzymes and serum bilirubin in all patients. The abnormalities of the enzymes levels persisted for abnormally long periods even when the serum bilirubin had come down and the patients had become asymptomatic. Blood for HBsAg and anti-HAV IgM was negative in all the patients except one in whom HBsAg was positive. Drugs could not be implicated as the cause of jaundice, all patients maintained recovery even after restarting antileprosy drugs. The possibility of non A, non B viruses producing hepatitis during the course of disease is brought out. Course of prolonged jaundice in leprosy is compared with other diseases which could result in a similar situation.

PY - 1987 SP - 194 EP - 202 T2 - Indian journal of leprosy TI - Leprosy, liver and jaundice. VL - 59 SN - 0254-9395 ER -