TY - JOUR
KW - Antigens, Bacterial
KW - Antigens, Differentiation, T-Lymphocyte
KW - Antigens, Surface
KW - Concanavalin A
KW - Humans
KW - Immune Tolerance
KW - leprosy
KW - Lipopolysaccharides
KW - Lymphocyte Activation
KW - Mycobacterium bovis
KW - Mycobacterium leprae
KW - Polysaccharides, Bacterial
KW - T-Lymphocytes
KW - Tuberculin
AU - Kaplan G
AU - Gandhi R R
AU - Weinstein D E
AU - Levis W R
AU - Patarroyo M E
AU - Brennan P J
AU - Cohn Z A
AB - <p>The extent to which M. leprae and its products induced suppression of T lymphocyte proliferation in vitro was evaluated. M. leprae antigens suppressed T cell proliferation in response to mitogens and antigens in both lepromatous and tuberculoid patients, as well as controls never exposed to M. leprae or M. leprae endemic areas. Both soluble and particulate fractions of M. leprae were found to suppress proliferation in a dose-dependent manner. The extent of suppression was inversely related to the proliferative response of the donors mononuclear cells to M. leprae. Evidence indicates that M. leprae contains both stimulatory and suppressive molecules for T cells. One such suppressive antigen, Lipoarabinomannan (LAM)-B of M. leprae, also suppressed the proliferative response of tuberculoid patients. Suppression was also observed with the LAM-B of M. tuberculosis. The suppressive effects observed were not due to the toxicity of the antigen. Some of the suppressive activity was mediated by T8+ suppressor cells and was expressed in both lepromatous and tuberculoid patients. We suggest that previous sensitization to M. leprae and other cross-reactive mycobacterial antigens determines the sensitivity of T cells to the suppressive effects of M. leprae antigens.</p>
BT - Journal of immunology (Baltimore, Md. : 1950)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3106496?dopt=Abstract
DA - 1987 May 01
IS - 9
J2 - J. Immunol.
LA - eng
N2 - <p>The extent to which M. leprae and its products induced suppression of T lymphocyte proliferation in vitro was evaluated. M. leprae antigens suppressed T cell proliferation in response to mitogens and antigens in both lepromatous and tuberculoid patients, as well as controls never exposed to M. leprae or M. leprae endemic areas. Both soluble and particulate fractions of M. leprae were found to suppress proliferation in a dose-dependent manner. The extent of suppression was inversely related to the proliferative response of the donors mononuclear cells to M. leprae. Evidence indicates that M. leprae contains both stimulatory and suppressive molecules for T cells. One such suppressive antigen, Lipoarabinomannan (LAM)-B of M. leprae, also suppressed the proliferative response of tuberculoid patients. Suppression was also observed with the LAM-B of M. tuberculosis. The suppressive effects observed were not due to the toxicity of the antigen. Some of the suppressive activity was mediated by T8+ suppressor cells and was expressed in both lepromatous and tuberculoid patients. We suggest that previous sensitization to M. leprae and other cross-reactive mycobacterial antigens determines the sensitivity of T cells to the suppressive effects of M. leprae antigens.</p>
PY - 1987
SP - 3028
EP - 34
T2 - Journal of immunology (Baltimore, Md. : 1950)
TI - Mycobacterium leprae antigen-induced suppression of T cell proliferation in vitro.
VL - 138
SN - 0022-1767
ER -