TY - JOUR KW - Corynebacterium KW - DNA, Bacterial KW - Genes, Bacterial KW - Humans KW - Kinetics KW - leprosy KW - Mycobacterium bovis KW - Mycobacterium leprae KW - Nocardia KW - Nucleic Acid Hybridization KW - Sequence Homology, Nucleic Acid AU - Antoine I AU - Coene M AU - Cocito C AB -

The genomes of Mycobacterium leprae and leprosy-derived corynebacteria (LDC), which have a similar base composition of guanine + cytosine 56 mol %, have been compared with those of reference bacteria of the CMN group (genera Corynebacterium, Mycobacterium, Nocardia). Genome sizes of three LDC strains were (1.2-2.5) x 10(6) base pairs. DNA from four of seven LDC strains examined had homology levels greater than 60%. Two other strains had a homology of 40% when compared with the CMN strains and one strain was distinctly different. The DNA from all seven LDC strains gave 0.3-18% hybridisation with that of M. leprae, 5-16% with reference corynebacteria, 5-12% with M. bovis, and 2-8% with Nocardia caviae. The small size of the LDC genome and its unrelatedness to those of M. leprae and organisms of the CMN group shows the uniqueness of LDC.

BT - Journal of medical microbiology C1 - http://www.ncbi.nlm.nih.gov/pubmed/3050108?dopt=Abstract DA - 1988 Sep DO - 10.1099/00222615-27-1-45 IS - 1 J2 - J. Med. Microbiol. LA - eng N2 -

The genomes of Mycobacterium leprae and leprosy-derived corynebacteria (LDC), which have a similar base composition of guanine + cytosine 56 mol %, have been compared with those of reference bacteria of the CMN group (genera Corynebacterium, Mycobacterium, Nocardia). Genome sizes of three LDC strains were (1.2-2.5) x 10(6) base pairs. DNA from four of seven LDC strains examined had homology levels greater than 60%. Two other strains had a homology of 40% when compared with the CMN strains and one strain was distinctly different. The DNA from all seven LDC strains gave 0.3-18% hybridisation with that of M. leprae, 5-16% with reference corynebacteria, 5-12% with M. bovis, and 2-8% with Nocardia caviae. The small size of the LDC genome and its unrelatedness to those of M. leprae and organisms of the CMN group shows the uniqueness of LDC.

PY - 1988 SP - 45 EP - 50 T2 - Journal of medical microbiology TI - Size and homology of the genomes of leprosy-derived corynebacteria, Mycobacterium leprae, and other corynebacteria and mycobacteria. VL - 27 SN - 0022-2615 ER -