TY - JOUR
KW - Animals
KW - Disease Models, Animal
KW - Immunologic Deficiency Syndromes
KW - leprosy
KW - Leukocytes, Mononuclear
KW - Male
KW - Mice
KW - Mice, Inbred CBA
KW - Mycobacterium leprae
KW - Phagocytes
KW - Time Factors
AU - Vishnevetskiĭ F E
AU - Iushin IM
AU - Aiupova A K
AU - Urliapova N G
AB - <p>CBA mice with induced insufficiency of mononuclear phagocyte system (MNPS) were inoculated intraplantar with M. leprae in a dose of 1 X 10(4). A significantly accelerated multiplication of M. leprae was noted in the sites of inoculation with the development of a generalized infections process and appearance in 6 months after inoculation of lepromatous structures in spleen, liver and other internal organs as compared with the animals with unchanged MNPS. The data obtained suggest that insufficiency in macrophage component of cell-mediated immunity might underline the sensibility to leprosy infection.</p>
BT - Biulleten' eksperimental'noi biologii i meditsiny
C1 - http://www.ncbi.nlm.nih.gov/pubmed/3058225?dopt=Abstract
DA - 1988 Nov
IS - 11
J2 - Biull Eksp Biol Med
LA - rus
N2 - <p>CBA mice with induced insufficiency of mononuclear phagocyte system (MNPS) were inoculated intraplantar with M. leprae in a dose of 1 X 10(4). A significantly accelerated multiplication of M. leprae was noted in the sites of inoculation with the development of a generalized infections process and appearance in 6 months after inoculation of lepromatous structures in spleen, liver and other internal organs as compared with the animals with unchanged MNPS. The data obtained suggest that insufficiency in macrophage component of cell-mediated immunity might underline the sensibility to leprosy infection.</p>
PY - 1988
SP - 574
EP - 8
T2 - Biulleten' eksperimental'noi biologii i meditsiny
TI - [Reproduction of experimental leprous infection in mice with a preliminary modelling of failure of the mononuclear phagocyte system].
VL - 106
SN - 0365-9615
ER -