False-positive HIV-2 serology poses a diagnostic challenge, particularly in chronic infectious or inflammatory diseases that induce polyclonal B cell activation. Leprosy, caused by , is one such condition known to produce immunologic cross-reactivity with HIV antigens. We report the case of a woman in her seventh decade with multibacillary Hansen's disease in a Type 1 (reversal) reaction who showed reactivity for HIV-2 antibodies on a fourth-generation chemiluminescent immunoassay despite having no risk factors for HIV-2 infection. She was clinically stable on multidrug therapy (MDT), and a confirmatory qualitative real-time PCR for HIV-2 RNA was negative, confirming a false-positive result. Laboratory tests showed mild anaemia and leucocytosis with normal hepatic and renal function. She was treated with corticosteroids while continuing MDT, with improvement over 3 weeks. This case highlights the need for confirmatory nucleic acid testing in hypergammaglobulinaemic states to avoid misdiagnosis, unnecessary therapy and social stigma.
BT - BMJ case reports C1 - https://www.ncbi.nlm.nih.gov/pubmed/42062072 DA - 04/2026 DO - 10.1136/bcr-2025-271642 IS - 4 J2 - BMJ Case Rep LA - ENG M3 - Article N2 -False-positive HIV-2 serology poses a diagnostic challenge, particularly in chronic infectious or inflammatory diseases that induce polyclonal B cell activation. Leprosy, caused by , is one such condition known to produce immunologic cross-reactivity with HIV antigens. We report the case of a woman in her seventh decade with multibacillary Hansen's disease in a Type 1 (reversal) reaction who showed reactivity for HIV-2 antibodies on a fourth-generation chemiluminescent immunoassay despite having no risk factors for HIV-2 infection. She was clinically stable on multidrug therapy (MDT), and a confirmatory qualitative real-time PCR for HIV-2 RNA was negative, confirming a false-positive result. Laboratory tests showed mild anaemia and leucocytosis with normal hepatic and renal function. She was treated with corticosteroids while continuing MDT, with improvement over 3 weeks. This case highlights the need for confirmatory nucleic acid testing in hypergammaglobulinaemic states to avoid misdiagnosis, unnecessary therapy and social stigma.
PY - 2026 T2 - BMJ case reports TI - False-positive HIV-2 serology in a patient with multibacillary leprosy. VL - 19 SN - 1757-790X ER -