TY - JOUR KW - Lepromatous leprosy diagnosis KW - Tuberculosis KW - Diagnostic test KW - Hermatologic Manifestations AU - González JFM AU - González ALR AU - Gamiño AED AU - López LC AU - Moreno FAR AU - García AVP AU - Sanchez MN AU - Montalvo CMG AU - Esquivel KGS AU - López MA AU - Romo AC AU - Rodríguez JG AU - Basurto IN AU - Herrera SRE AU - Martínez MJS AU - Velasco KTG AU - Durón AXM AB - This report details the clinical evolution of a 23-year-old male presenting with the exceptionally rare co-occurrence of active lepromatous lerosy and tuberculous lymphadenitis, complicated by severe immune thrombocytopenia. The patient’s presentation—spanning chronic dermatological findings, acute systemic symptoms, and profound hematological disturbance—required a multifaceted diagnostic approach culminating in histopathological and microbiological confirmation of both mycobacterial infections. Management was successfully integrated, utilizing a single rifampin-based antitubercular regimen to simultaneously address both diseases, resulting in resolution of thrombocytopenia and significant clinical improvement. This case highlights the diagnostic complexity in co-endemic regions, the potential for tuberculosis to drive significant parainfectious hematologic complications, and the feasibility of a unified pharmacological strategy for dual mycobacterial disease. BT - International Journal of Medical Science and Clinical Research Studies DA - 12/2025 DO - 10.47191/ijmscrs/v5-i12-20 IS - 12 LA - ENG M3 - Article N2 - This report details the clinical evolution of a 23-year-old male presenting with the exceptionally rare co-occurrence of active lepromatous lerosy and tuberculous lymphadenitis, complicated by severe immune thrombocytopenia. The patient’s presentation—spanning chronic dermatological findings, acute systemic symptoms, and profound hematological disturbance—required a multifaceted diagnostic approach culminating in histopathological and microbiological confirmation of both mycobacterial infections. Management was successfully integrated, utilizing a single rifampin-based antitubercular regimen to simultaneously address both diseases, resulting in resolution of thrombocytopenia and significant clinical improvement. This case highlights the diagnostic complexity in co-endemic regions, the potential for tuberculosis to drive significant parainfectious hematologic complications, and the feasibility of a unified pharmacological strategy for dual mycobacterial disease. PB - Everant Journals PY - 2025 SP - 2058 EP - 2062 T2 - International Journal of Medical Science and Clinical Research Studies TI - Concurrent Lepromatous Leprosy and Active Tuberculosis in A Young Male: A Complex Diagnostic and Therapeutic Challenge with Hematologic Manifestations UR - https://www.researchgate.net/publication/399198549_Concurrent_Lepromatous_Leprosy_and_Active_Tuberculosis_in_A_Young_Male_A_Complex_Diagnostic_and_Therapeutic_Challenge_with_Hematologic_Manifestations/fulltext/695429bc27359023a011d2ab/Concurrent-Lepromato VL - 05 SN - 2767-8326, 2767-8342 ER -