TY - JOUR
KW - Multibacillary leprosy
KW - Bacterial index
KW - IL-10
AU - Fitriyanti 
AU - Lipinwati 
AU - Istarini A
AU - Ekaputri TW
AU - Nastiti NI
AU - I Made Dwi Mertha Adnyana 
AB - <p><strong>Background</strong></p>

<p>Multibacillary (MB) leprosy is characterised by a high bacillary burden and a tolerogenic immune profile. Interleukin-10 (IL-10) is a key immunoregulatory cytokine that may reflect bacillary load. Objective: To compare bacillary burden and IL-10 between MB patients and controls and to examine the correlation between the Bacterial Index (BI) and IL-10 among MB patients.</p>

<p><strong>Methods</strong></p>

<p>A comparative cross-sectional study included 68 participants (MB n=34; controls n=34). Categorical variables were analysed using Chi-square tests, and medians were used with Mann–Whitney U tests. Spearman’s rank correlation was used to assess the BI–IL-10 relationship in MB.</p>

<p><strong>Results</strong></p>

<p>Age distribution was similar between groups (p=0.451), whereas occupation (p=0.040) and education (p=0.027) differed. BI was markedly higher in MB than in controls (median 2.5 [IQR 4] vs 0 [0]; p&lt;0.001). IL-10 concentrations were also higher in MB (1.96 [4.03] pg/mL) than in controls (1.12 [1.94] pg/mL; p=0.029). Among MB patients, BI correlated positively with IL-10 (ρ = 0.358; p = 0.038).</p>

<p><strong>Conclusion</strong></p>

<p>MB leprosy shows substantially greater bacillary burden and elevated IL-10 relative to controls. The positive association between BI and IL10 supports the role of an immunoregulatory milieu linked to bacillary load. These findings highlight IL-10 as a potential biomarker for disease burden in MB leprosy and warrant validation in larger, adjusted cohorts.</p>

BT - Jambi Medical Journal
LA - ENG
M3 - Article
N2 - <p><strong>Background</strong></p>

<p>Multibacillary (MB) leprosy is characterised by a high bacillary burden and a tolerogenic immune profile. Interleukin-10 (IL-10) is a key immunoregulatory cytokine that may reflect bacillary load. Objective: To compare bacillary burden and IL-10 between MB patients and controls and to examine the correlation between the Bacterial Index (BI) and IL-10 among MB patients.</p>

<p><strong>Methods</strong></p>

<p>A comparative cross-sectional study included 68 participants (MB n=34; controls n=34). Categorical variables were analysed using Chi-square tests, and medians were used with Mann–Whitney U tests. Spearman’s rank correlation was used to assess the BI–IL-10 relationship in MB.</p>

<p><strong>Results</strong></p>

<p>Age distribution was similar between groups (p=0.451), whereas occupation (p=0.040) and education (p=0.027) differed. BI was markedly higher in MB than in controls (median 2.5 [IQR 4] vs 0 [0]; p&lt;0.001). IL-10 concentrations were also higher in MB (1.96 [4.03] pg/mL) than in controls (1.12 [1.94] pg/mL; p=0.029). Among MB patients, BI correlated positively with IL-10 (ρ = 0.358; p = 0.038).</p>

<p><strong>Conclusion</strong></p>

<p>MB leprosy shows substantially greater bacillary burden and elevated IL-10 relative to controls. The positive association between BI and IL10 supports the role of an immunoregulatory milieu linked to bacillary load. These findings highlight IL-10 as a potential biomarker for disease burden in MB leprosy and warrant validation in larger, adjusted cohorts.</p>

PY - 2025
SP - 1
EP - 7
T2 - Jambi Medical Journal
TI - Correlation of IL-10 Levels with the Bacterial Index in Multibacillary Leprosy
UR - https://scholar.google.nl/scholar_url?url=https://online-journal.unja.ac.id/kedokteran/article/download/48898/22494&hl=nl&sa=X&d=5070911690763126283&ei=NJobaYbxJ_-j6rQPhJXOgAY&scisig=ABGrvjIE-TXf8O4TQ6WsYQmqvIij&oi=scholaralrt&hist=732gnZIAAAAJ:7757451093
ER -